I love listening to podcasts. They have replaced TV shows. Here's a list I would recommend:

If you're into knitting:
:: Cast On
:: Stash & Burn

:: NPR: Planet Money (really good at explaining what the heck is going in the global economy)
:: Savage Love Podcast (audio version of Dan Savage, the sex columnist)
:: Stuff You Should Know (geeky-cool science show)
:: This American Life (interesting stories about people from every walk of life)

These podcasts are both informative and entertaining. All can be found on iTunes.